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Thursday, January 7, 2010

Is it Possible???

Yes... Yes it is my friends! A new prohormone has been released! (OK, don't get too excited it's more like a re-release, but I'll write about it anyway) and it just warms my heart to type those words. I thought the era of prohormones was over with the January 2010 ban; but how could I be so foolish. OK, I've expressed enough excitement for one paragraph. WAIT FOR IT!!! annnnd the "new" re-release is... ALPHA ONE by CEL.

Here we go... CEL makes clones, that's what they do and I have no disrespect for them because they provide a whole array of different, pure compounds to the consumer; and we the consumer appreciate that. The name is Alpha One, so the first thing that comes to mind is, this is a Methyl-1 Alpha clone. Methyl-1 Alpha was released by Legal Gear, about a year after the 2004 ban. I believe it was their follow up product to M-1-P. I took a look at the active compound listed and sure enough, Methyl-1-Etiocholenolol-Epietiocholanolone. The same ingredient that was listed in M-1-A, now that is where the easy part came to an end.

Armed with the simple knowledge that Alpha One was the same as M-1-A, I set off to write just that... Then I realized know one actually knows what the hell it is. Just looking at the ridiculous nomenclature one would think it is two compounds. Etiocholane is just another word for 5b-androstane(Figure 1);
Figure 1.

This term is used to denote a single 19-carbon steroid structure, listing it twice would mean there are two separate molecules. The label lists the entire name @ 20mg of, therefore we already know the nomenclature is wrong. Now, I don't believe methyl-1-etiocholenolol is even close to being an IUPAC nomenclature, but I will still break it down.From past experience we know methyl-1-test(Figure 2) is a testosterone molecule with a 17-alpha methyl group added for oral bioavailability and the double bond in the first ring is located at the 1 position instead of the 4 position, found in testosterone. So I will assume that this is a 17-alpha alkylated steroid being that the name starts with methyl. Next the etiocholane name is changed to have an -en instead of the -an which would show that it is not 5-alpha or 5-beta reduced and that it does contain a double bond in the molecule.The 1 in the name denotes this double bond @ the 1 position. Finally the -olol at the end denotes a diol, meaning there are -OH groups at the 3rd and 17th position. This would give us a diol version of methyl-1-testosterone(Figure 3), which would be a direct precursor to M-1-T with the conversion of the -OH @ the 3 position in the first ring.





Then there is a epietiocholanolone just thrown on the end. Epietiocholanolone is another name for epi-5-beta androsterone(Figure 4). So this is an androstane with an-OH @ the 3 position and a ketone @ the 17 position. In my humble opinion this is a worthless compound, it would take two conversions to become active. The 17-keto would have to be converted to an -OH and the -OH @ the 3 position would have to be converted to a ketone. This would produce a 5-alpha reduced androgen = DHT.
Those are the two compounds that I would hypothesize to be in this supplement. However, according to a post from William Llewellyn @ BB.com and a rumored quote from Patrick Arnold, this compound is 7a-Methylandrost-1-ene-3b-ol-17-one(Figure 5).
Which is basically Androsterone with a double bond @ the 1 position and a methyl group at the 7 position. So this product requires conversions at the 1st and 17th position to become the active form of 7a-methyl-1-testosterone(Figure 6).
If this is true, this would be a fairly weak prohormone to 1-testosterone or 7a-methyl-1-testosterone. However, the bottle is dosed @ 20mg's a pill and has a max dose of 60mg's, for a max of three weeks. It is also not recommended as a first time PH; H-Drol and E-Stane are suggested to be weaker. This would mean that there is a fairly strong, most likely 17alpha alkylated PH in there. If it were an androsterone derivative it would be dosed much higher for a longer pereiod of time. My hypothesis is that it is either a diol version of M-1-T(Figure 3) or a diol version of 7a-M-1-T(Figure 7). Now, if that is the case you can expect the diol version of M-1-T to be as M-1,4-AD is to D-Bol or as Halodrol and clones are to Turinabol(because M-1,4-AD is a diol version of D-Bol and H-Drol a diol version of T-Bol).

If it is the 7-alpha alkylated version I would expect it to be extremely androgenic. This is because M-1-T is 5-alpha reduced (lacking the 4-ene) which adds to androgenicity, similar to DHT. M-1-T is actually 2220% more androgenic than normal testosterone. I believe the addition of the 7a-methyl group will increase the androgenicity even more. Because this modification has been used before for the purpose of male contraceptives ie. 7a-methyl-19-nortestosterone(MENT). This is a nandrolone molecule with a 7-alpha alkylation to increase androgen receptor binding of nandrolone. It cannot be 5-alpha reduced so it will not be as active in the prostate but will still bind strongly to androgen receptors to cause the testes to shut down.

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