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Wednesday, June 24, 2009

Applied Neutriceuticals New Designer, The One

Applied Neutriceuticals in my humble opinion seems to be a straight shooting, honest company whose goal is to produce progressive supplements with good real world results.... and no I do not work for them or any supplement company for that matter. My judgment about this company is not based on experience being that I have not tried any of AN's supplements. It is based upon the buzz they have created on the internet and the fact that they list their ingredients with the actual ingredients and amounts. They have also made their way in to vitamin shoppe which leads me to believe they are pretty hot right.
Ok, enough BS, The One! that's what I want to talk about. The One is described as a pro-hormone to DHT that is 3-5 times more potent than testosterone. It also comes with Second Gear which is a support supplement to be taken during your cycle. The One contains 22.5mg of the active ingredient 17a-methyl-etioallocholan-17b-ol-3-hydroxyimine which is taken twice a day. The molecule is pictured below.
What you are looking at is a precursor to a hormone but it's not exactly DHT. It's methyl DHT! This is a strait forward pro-hormone with simple chemistry. This is methyl DHT that has been reacted with a hydroxylamine. The hydroxylamine reacts with the ketone at the third position and produces an oxime which is the N-OH double bonded at the third position in the molecule above. Overly simplified paint version of the reaction below.
So now you have an oxyimine what's the big deal? Well the big deal my friend is that you have a molecule which is not methyl DHT.... Place it in an acidic environment such as... your stomach and... BOOM that good old oxyimine is cleaved and replaced with a ketone. In lay man's terms your stomach acid turns The One into methyl DHT. AN claims that this is 3-5 times more powerful than testosterone well according to a research article provided by Methyl DHT is 3.8 times more anabolic and 1.6 times more androgenic than testosterone. I would be a little scared actually taking DHT but other than that sounds pretty good for a legal alternative.

Once you have finished your cycle of The One you need to finish it off with a nice PCT, so grab your second gear. Since second gear is nothing novel I'll make this quick. Second gear is a 550mg blend of Milk Thistle, Avena Sativa 10:1, 13-C (Indole-3-Carbinol), 6-Bromodione (6-bromo-etioallocholan-4-ene, 17-dione;50% Alpha/50% Beta)*.......50mg. Let's break this down milk thistle to support the liver, like it. Avena Sativa to prevent your elevated hormone levels from being bound by SHBG, like it. 13-c possibly anti-carcinogenic, possibly anti-estrogenic, I'll take it. 6-bromodione with a 50/50 racemic index of alpha and beta isomer, from what I hear one isomer is an aromatase inhibitor and the other is androgenic, love it!

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